Art works which engage with the topic of human enhancement and evolution have begun appearing parallel to increased awareness about anthropogenic changes to our environment and acceleration of the speed of technological developments that impact us and our biological environment. The article connects artistic activity with play activity and evolution, which are considered on two levels. On the first level, play activity and its beneficial role to evolution is introduced through various science scholars’ research. On the second level, artistic activity that engages with human enhancement and related topics is proposed as play activity for adults, which simultaneously experiments directly with ideas concerning evolution and human development. The author proposes that these kinds of experimental art projects support our mental adaptation to evolutionary changes.