First passage time analysis of spatial mutation patterns reveals evolutionary dynamics of pre-existing resistance in colorectal cancer

Keyphrases

• Mutation Pattern 100%
• Tumor 100%
• Evolutionary Dynamics 100%
• Spatial mutation 100%
• Colorectal Cancer 100%
• Population Mixtures 40%
• Early Cancer 40%
• Cell Mixing 40%
• Cancer Dynamics 40%
• Tumor Cell Subpopulations 40%
• Mutant Cells 40%
• First Passage Time 40%
• Subclonal 40%
• Computational Model 20%
• Spatial Arrangement 20%
• Random Walk 20%
• Agent-based Model 20%
• Mixing Patterns 20%
• Pattern Structures 20%
• Therapy-resistant 20%
• Simulated Pattern 20%
• Human Colorectal Cancer 20%
• Subclone 20%
• Toy Model 20%
• Tumor Cells 20%
• First-passage Probability 20%
• Clonal Dynamics 20%
• Small Size Sample 20%
• Spatial Architecture 20%
• Emergence Time 20%
• Point mutation 20%

Immunology and Microbiology

• Dynamics 100%
• Evolution 100%
• Tumor Cell 50%
• Cell Mutant 33%
• Cell Population 33%
• Wild Type 16%
• Point Mutation 16%

Biochemistry, Genetics and Molecular Biology

• Dynamics 100%
• Evolution 100%
• Cell Mutant 33%
• Genetics 16%
• Point Mutation 16%
• Wild Type 16%